@article {549266,
	title = {A single amino acid mutation contributes to adaptive beach mouse color pattern},
	journal = {Science},
	volume = {313},
	number = {5783},
	year = {2006},
	note = {<p>Hoekstra, Hopi EHirschmann, Rachel JBundey, Richard AInsel, Paul ACrossland, Janet PengP40-RR14279/RR/NCRR NIH HHS/Research Support, N.I.H., ExtramuralResearch Support, U.S. Gov{\textquoteright}t, Non-P.H.S.New York, N.Y.2006/07/11 09:00Science. 2006 Jul 7;313(5783):101-4.</p>},
	month = {Jul 7},
	pages = {101-4},
	abstract = {<p>Natural populations of beach mice exhibit a characteristic color pattern, relative to their mainland conspecifics, driven by natural selection for crypsis. We identified a derived, charge-changing amino acid mutation in the melanocortin-1 receptor (Mc1r) in beach mice, which decreases receptor function. In genetic crosses, allelic variation at Mc1r explains 9.8\% to 36.4\% of the variation in seven pigmentation traits determining color pattern. The derived Mc1r allele is present in Florida{\textquoteright}s Gulf Coast beach mice but not in Atlantic coast mice with similar light coloration, suggesting that different molecular mechanisms are responsible for convergent phenotypic evolution. Here, we link a single mutation in the coding region of a pigmentation gene to adaptive quantitative variation in the wild.</p>},
	keywords = {*Mutation, Adaptation, Biological, Alleles, Amino Acid Substitution, Animals, Cell Line, Crosses, Genetic, Cyclic AMP/metabolism, Female, Florida, Gene Frequency, Genotype, Hair, Hair Color/*genetics, Humans, Male, Molecular Sequence Data, Peromyscus/*genetics, Phenotype, Pigmentation/*genetics, Polymorphism, Single Nucleotide, Principal Component Analysis, Receptor, Melanocortin, Type 1/chemistry/*genetics/metabolism, Sequence Analysis, DNA},
	isbn = {1095-9203 (Electronic)0036-8075 (Linking)},
	author = {Hoekstra, HE and Hirschmann, R. J. and Bundey, R. A. and Insel, P. A. and Crossland, J. P.}
}
